Endocrine Abstracts

Objective: One of the common features of hypothyroidism is weight gain or failure to lose weight. Also bradycardia and mild hypertension can be seen. Impact of thyroid hormone deficiency on glucose and insulin metabolism is not fully understood. Thyroid hormones play role in lipid synthesis, metabolism and mobilization. Metabolic syndrome is a state which most features of hypothyroidism can be seen. Our aim is to investigate the frequency of metabolic syndrome in hypothyroid p...

Objective: Thyroid hormones directly or indirectly, through erythropoietin, stimulate growth of erythroid colonies. Anemia is often the first sign of hypothyroidism. Hypothyroidism can lead to a wide variety (%20–60) of anemic disorders. Numerous mechanisms are involved in the pathogenesis of these anemias which can be microcytic, macrocytic and normocytic. Microcytic anemia is usually ascribed to malabsorption of iron and loss of iron by menorrhagia. Macrocytic anemia is...

Introduction: Diabetes mellitus (DM) has been associated with abnormalities of cardiac function and left ventricular hypertrophy. Diabetic individuals, particularly women, had higher heart rates, greater left ventricular wall thicknesses, greater cardiac mass than unaffected subjects. We aimed to investigate association between waist circumference–body mass index (BMI) and left ventricle mass (LVM)-left ventricle mass index (LVMI), left ventricle myocardial perfusion inde...

Background: Diabetic foot ulcer and lower extremity amputation are leading causes of mortality and morbidity in diabetic patients. Diabetic neuropathy and peripheral vascular disease are major reasons for diabetic foot ulcer. Most of the studies showed that hyperhomocystinemia is related with microvascular and macrovascular complications in diabetic patients. Also hyperhomocysteinemia is related to poor ulcer healing. In this study, we investigated the relationship of hyperhom...

Background: Ca 19-9 is a tumor-associated antigen. In this study, we aimed to compare Ca 19-9 levels in type 2 diabetes mellitus (DM) patients and healthy control group.Method: Two hundred and fifteen type 2 DM patients (82 male and 133 female) and 209 healthy control group (79 male, 130 female) age, sex and body mass index(BMI) matched were included in the study. Duration of diabetes, HbA1c and presence of complications were analyzed. Cases with high se...

Objective: Diabetic foot ulcer is associated with increased morbidity and mortality. The most important factor related to the development of foot ulcer is peripheral neuropathy. Thrombin-activatable fibrinolysis inhibitor (TAFI) is associated with coagulation, fibrinolysis and inflammation. Plasma TAFI may participate in arterial thrombosis in cardiovascular diseases (CVD). TAFI may be involved in the mechanism of vascular endothelial damage in diabetic patients. The aim of th...

Endothelial dysfunction is assessed noninvasively by measuring flow-mediated dilation (FMD). However, FMD is strongly dependent on arterial size, which contributes to a wide range of FMD values. It was previously shown that FMD is greater in small arteries, because the shear stimulus during postocclusion hyperemia is greater in small arteries. We aimed to investigate the predictive value of brachial arterial size on FMD in 44–61 years old Turkish women while adjusting for...

Women with a history of GDM may be at increased risk for future diabetes and cardiovascular disease. The aim of this study was to investigate the endothelium dependent hemostatic factors as well as the parameters of endothelial function and inflammation in women with pGDM.Eighty women with pGDM and 40 women (control) healthy women with normal glucose tolerance during pregnancy were studied. In all women, plasma glucose, insulin, C-peptid, lipid profile, ...

Paraoxonase is a high-density lipoprotein-bound antioxidant enzyme that inhibits atherosclerosis. Metabolic syndrome is a combination of several metabolic abnormalities and known to be related with increased cardiovascular events. The most important component of metabolic syndrome which have impact on oxidative stress is diabetes, the most severe form of disturbed carbohydrate metabolism. The effect of metabolic syndrome on oxidative stress and paroxonase-1 (PON-1) activity ha...

Objective: Acromegaly is associated with increased morbidity and mortality, mostly due to cardiovascular complications. Thrombin-activatable fibrinolysis inhibitor (TAFI) is associated with coagulation/fibrinolysis and inflammation. Plasma TAFI may participate in arterial thrombosis in cardiovascular diseases (CVD). In this study, we aimed to evaluate the levels of TAFI antigen and also its relationship with other markers in a group of patients with acromegaly in compoa...